Eighty percent of the outbreaks (20/25) involved infections of the bloodstream or urinary tract. There are mainly two pathotypes that pose a threat to our health: hypervirulent (hvKp) and classical (cKp). To get a Klebsiella infection, a person must be exposed to the bacteria. The most important mechanism of resistance is the production of a carbapenemase enzyme that has the ability to hydrolyze carbapenems [].Since its first description in North Carolina in 1996 [], carbapenemase-producing K. pneumoniae (KPC) has been identified in 24 states . Klebsiella pneumoniae causes serious epidemic and endemic nosocomial infections. Herein, we evaluate the incidence of meropenem/vaborbactam-resistance among KPC-producing K. pneumoniae (KPC-Kp) bloodstream infection in a large Italian hospital. The prevalence of HV phenotype was 66.7% (22/33) of K. pneumoniae CSF isolates in general, and was specifically in the subgroups of the isolates as follows: (1), 95.0% (19/20) of primary meningitis. It causes various hospital-acquired infections, such as pneumonia (hence the name) and is the third most common cause of . Patients and Methods: A total of 6328 strains of CRKP were collected from 2017 to 2019. Circles represent the reported data, and solid and dotted lines represent the fit with variable between-country and uniform for all hospital transmission rates, respectively. Klebsiella pneumoniae carbapenemase-producing Kp (KPC-Kp) is a major bacterial pathogen responsible for hospital outbreaks worldwide ( Lee et al., 2016 ), mainly via the spread of high-risk clones and epidemic resistance plasmids ( Mathers et al., 2015 ). 2016;11:809-23. Keywords:Klebsiella pneumoniae, extended-spectrum -lactamase, molecular typing, nosocomial infection, epidemiology, molecular typing. Klebsiella (K.) pneumoniae is a gram-negative, facultative anaerobic, non-motile, and non-flagellated bacillus that is a member of the Enterobacteriaceae family. It is one of the most frequently isolated organisms after Escherichia coli from clinical specimens in Nepal [ 2] and has a greater clinical significance. from 2006 to 2010. Carbapenem-resistant Enterobacterales (CRE) Enterobacterales are a large order of different types of germs (bacteria) that commonly cause infections in healthcare settings. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Klebsiella pneumoniae is a major cause of hospital-acquired infections, mainly responsible for urinary, respiratory, and bloodstream infections, as well as infections in intensive care unit (ICU) patients. We divided the patients into two groups . A total of 293 incidences of KP-BSIs were identified in a 5-year period, 22.18% of these (65/293) were CRKP strains, and the proportion of CRKP-BSI in ICU was 59.62% (31/52), equaling the levels observed in the epidemic regions. Conclusion. Klebsiella pneumoniae is an opportunistic Gram-negative bacterium responsible for several of nosocomial infections including urinary tract infections, pneumonia, and septicemia [ 1 ]. Antibiotics are commonly used as therapy and disease control in humans and animals. Radiograph findings should not be used to make a diagnosis of Klebsiella pneumoniae infection definitively. The aim of this study was to evaluate the geographic and phylogenetic distribution of K. pneumoniae isolates of different antibiotypes, both at a national and a global scale. Klebsiella Pneumoniae Infections Epidemiology . The development of both in vitro and in vivo models of infection will lead to further elucidation of the molecular pathogenesis of K. pneumoniae. Klebsiella pneumoniae is a major cause of hospital-acquired infections, mainly responsible for urinary, respiratory, and bloodstream infections, as well as infections in intensive care unit (ICU) patients. Klebsiella pneumoniae : Epidemiology, Microbiology, Pathogenesis, and Clinical Management (Jon Persichino, Made Sutjita, Daniel Kim, Loma Linda University School of Medicine and University of California, Riverside School of Medicine, Riverside, CA, USA) C-9154 Derivatives with Potent In vitro Biological Activity against Klebsiella pneumoniae Eighty percent of the outbreaks (20/25) involved infections of the bloodstream or urinary tract. Klebsiella pneumoniae ( K. pneumoniae) is one of the leading causes of hospital-acquired and community-acquired infections in the world. Klebsiella pneumonia is a gram-negative bacteria that typically cause nosocomial infections and shows a great deal of antibiotic resistance. K. pneumoniae is responsible for 6-17% of UTI's, 7-14% of pneumonia, 4-15% of septicemia, 2-4% of wound infections, 4-17 nosocomial infections in intensive care units, and 3-20% of all neonatal septicemia cases. It is imperative to understand risk factors, prevention strategies, and therapeutic avenues to treat multidrug-resistant Klebsiella infections. As for most opportunistic infections, the role of host factors as well as bacterial traits are crucial in determining the outcome of infections. Klebsiella pneumoniae is a gram-negative that is associated with nosocomial and community-acquired infections. Of 824 unique patient isolates, 34% were presumptive ESBL producers. INTRODUCTION. The increasing prevalence of multidrug resistant (MDR) pathogens causing nosocomial infection constitutes a major health problem [1]. Meropenem/vaborbactam-resistance was found in 8% (n = 5) KPC-Kp, while 5% (n = 3) strains exhibited cross . However, the widespread use of antibiotics may also trigger the rise of antibiotic . It is responsible for about 1% of bacterial pneumonia. 36,37,43,73 Several additional risk factors for colonization and infection with ESBL-producing organisms have been reported, including the following: arterial and central venous catheterizatio. 3 Lbbert C, Faucheux S, Becker-Rux D, et al. We studied antimicrobial-resistant Klebsiella pneumoniae for 1998-2010 by using data from The Surveillance Network. The model was fitted to the data of the annual prevalence of resistance in Klebsiella pneumoniae reported by ECDC from 2005 to 2015. Brandon Kitchel Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. During study period (From December,2014 to April, 2015), 17(17%) strains were belonged to Klebsiella pneumoniae,12 (70.6%) were recovered from stool samples and 5(29.4%) from umbilical infections, (Table 1).Recently, K.pneumoniae from stool samples was documented among children attending different hospitals in Dar es Salaam, Tanzanid 22.Another report identified 12(2%) prevalence rate for . Reports on the isolation of K. pneumoniae from other sources are increasing, many of which express multidrug-resistant (MDR) phenotypes. Plasmid profile, restriction fragment length polymorphism (RFLP) patterned by an rRNA probe, and capsule serotyping of 143 Taiwan local bacteriemic isolates of Klebsiella pneumoniae were analyzed. We conducted a literature review to characterize the epidemiology of epidemic K. pneumoniae outbreaks. It is found in the respiratory tract and stools of about 5% of normal individuals. Klebsiella pneumoniae may be diagnosed with imaging . Infections produced by Klebsiella pneumoniae are relatively rare, and hospital settings have the the highest prevalence of cases. All of these cases rank within at least the top 11 in comparison to all other bacterial pathogens. Lancet Infect Dis 2013; 13: 785-96. Klebsiella pneumoniae is considered an opportunistic pathogen, constituting an ongoing health concern for immunocompromised patients, the elderly, and neonates. The causative microbe varied significantly depending on the diagnostic method: in cases diagnosed using PNEU-1, Staphylococcus aureus (21.3%) and Klebsiella pneumoniae (12.5%) were the dominant organisms, whereas in other VAP cases, Acinetobacter baumannii (23.8%) was commonly observed. Klebsiella pneumoniae (Kp) are Gram-negative bacteria that can cause various infections. For example, Klebsiella must enter the respiratory (breathing) tract to cause pneumoniae, or the blood to cause a bloodstream infection. Antibiotic resistance occurs when the germs no longer respond . Keywords: OXA-48; OXA-48-producing Klebsiella pneumoniae; ST11; carbapenemases; genomic analysis; hospital outbreak; phylodynamics. . 23. Rapid emergence of secondary . Klebsiella pneumoniae is a Gram-negative rod-shaped bacteria, which belongs to a family of bacteria called the Enterobacteriaceae. 2 Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Publication types Research Support, Non-U.S. Gov't MeSH terms . A number of KP-BSIs (114), obtained from January 1, 2014, to December 31, 2015, were further investigated. and . Klebsiella pneumoniae was an urgently defined threat in the rise of multi-drug-resistant hospitals and hyper virulent strains. The ESBL-producers were also molecularly analyzed and included the CTX-M, TEM and SHV genes. Klebsiella species are a Gram-negative rod shaped bacteria belonging to the Enterobacteriaceae family. Experts refer to them as Gram-negative, encapsulated, and nonmobile bacteria. Klebsiella pneumoniae is a member of the Klebsiella genus of Enterobacteriaceae and belongs to the normal flora of the human mouth and intestine. "Currant jelly" sputum is a hallmark of infection with Klebsiella pneumoniae. The emergence and dissemination of carbapenem resistance among Enterobacteriaceae, especially Klebsiella pneumoniae, constitute a serious threat to public health, since carbapenems are the agents of last resort in the treatment of life-threatening infections caused by drug-resistant Enterobacteriaceae.In K. pneumoniae, carbapenem resistance was first reported a decade ago and has subsequently . We conducted a literature review to characterize the epidemiology of epidemic K. pneumoniae outbreaks. Abstract: Introduction: Klebsiella pneumoniae is a common cause of nosocomial infections; however, there is limited information in Iran regarding nosocomial outbreaks due to extended-spectrum -lactamase . Close this message to accept cookies or find out how to manage your cookie settings. Since then, these versatile -lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. Klebsiella pneumoniae poses an urgent public health threat, causing nosocomial outbreaks in different continents. Epidemiology of Carbapenemase- Producing Klebsiella pneumoniae in a Hospital, Portugal We aimed to provide updated epidemiologic data on carbape- nem-resistant Klebsiella pneumoniaein Portugal by charac- terizing all isolates (N = 46) recovered during 2013-2018 in a 123-bed hospital in Lisbon. Klebsiella pneumoniae isolates were 21% (325/1553) of all collected over that period of one year. Gram-negative bloodstream infections (GNBSI), predominantly caused by Escherichia coli and Klebsiella spp., are a significant and increasing threat to public health. K. pneumoniae. Skip to main content Accessibility help We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Therefore, this study aimed to determine the prevalence of ESBL producing Escherichia coli and Klebsiella pneumoniae fecal carriage among children under five years in Addis Ababa . Extended-spectrum--lactamase (ESBL)- and carbapenemase-producing bacteria are widespread in hospitals, but the extent of this problem in long-term care facilities (LTCFs) is poorly understood. and 725 isolates of . The mortality described among patients infected with organisms positive for KPC is high, perhaps as a . Susceptibility results (n = 3,132,354) demonstrated significant increases in resistance to all antimicrobial drugs studied, except tetracycline. It helps to recognize the causes of current and forecasted trends by exploring . Epidemiology and Virulence of Klebsiella pneumoniae, Page 1 of 2 Abstract Strains of Klebsiella pneumoniae are frequently opportunistic pathogens implicated in urinary tract and catheter . Our results indicate that K1 and K2 are probably the most prevalent serotypes in Taiwan, accounting for 39% of total isolates tested. Abstract. E. Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in Greece. The sporadic detection of isolates belonging to other STs (e.g., ST101 and ST147) also have characterized the epidemiology of KPC K. pneumoniae in Italy ( 19 ). Klebsiella pneumoniae, a common gut bacteria, causes problems when it moves outside the gut and causes infection. Adequate empirical therapy was administered in 74% of infections caused by non-ESBL non-KPC strains, versus 33% of ESBL and 23% of KPC cases (p < 0.0001). Virulence factors are capsular antigens, adherence factors, the O-lipopolysaccharide, and siderophores promoting infectivity. Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. We aimed to elucidate, in the Portuguese regional clinical context, the relevance of LTCFs as a reservoir of Escherichia coli and Klebsiella spp. These days, multidrug-resistant strains are being increasingly reported from different countries. Epidemiology. Meropenem/Vaborbactam (MEM-VAB) is a novel carbapenem- -lactamase inhibitor active against KPC-producing Enterobacteria. Klebsiella pneumoniae is a contagious bacteria that can cause infections such as pneumonia and sepsis. Reports on the isolation of K. pneumoniaefrom other sources are increasing, many of which express multidrug-resistant (MDR) phenotypes. Klebsiella pneumoniae . K. pneumoniae has emerged as a major clinical and public health problem due to the rising prevalence of the infections caused by emerging multidrug-resistant strains [ 6, 7, 12 ]. They are now the leading cause of bloodstream infection (BSI) in the UK with a substantial associated burden of morbidity and mortality [1, 2].Despite becoming a significant public health concern and policy focus, their incidence . Data on the prevalence of ESBL fecal carriage remain scarce in Ethiopia. The most common subtype of the K. pneumoniae strains is classic K. pneumoniae (cKp) notorious for their resistance to common antibiotics [ 1, 2, 3 ]. Infections with K. pneumoniae are usually hospital-acquired and occur primarily in patients with impaired host defenses. An It is imperative to understand risk factors, prevention strategies, and therapeutic avenues to treat multidrug-resistant Klebsiella infections. In 1999, the molecular epidemiology of K. pneumoniae with extended-spectrum -lactamases (ESBLs) was studied at 15 hospitals in Brooklyn. Epidemiologic studies suggest that widespread use of third-generation cephalosporins is a major risk factor for selection of ESBL-producing K. pneumoniae. Out of the 384 study patients, 18 met these criteria giving the prevalence of Klebsiella pneumoniae at the AIC Kijabe hospital during the period of study to be 8.6% (95% CI: 9.4 Examples of germs in the Enterobacterales order include Escherichia coli ( E. coli) and Klebsiella pneumoniae. increased from 5.5% and 0.5% in 2006 to 20.4% and 4. . Strains of carbapenemase-producing Klebsiella pneumoniae (CPKP) have been identified since the 1990s and have rapidly spread in many countries [ 1 ]. Klebsiella pneumoniae is a "superbug" that causes a range of diseases, depending on which part of the body it infects. E. coli . The Klebsiella Pneumoniae Infections epidemiology section provides insights about the historical and current Klebsiella Pneumoniae Infections patient pool and forecasted trends for individual seven major countries. Klebsiella pneumoniaeis considered an opportunistic pathogen, constituting an ongoing health concern for immunocompromised patients, the elderly, and neonates. The emergence of these bacteria exhibiting multiple antibiotic resistance phenotypes has made the treatment and management of K. pneumoniae urinary-tract infections (UTIs) difficult (1 - 4). 2020. Related symptoms can include fever and a productive cough. We aimed to provide epidemiological research data, formulate appropriate combined treatment schemes, reasonably select antibiotics, and standardize nosocomial infection control schemes. Klebsiella pneumoniae ( K. pneumoniae) has emerged as a major pathogen of international concern due to the increasing incidences of hypervirulent and carbapenem-resistant strains. In a 5-year study, there were 1359 isolates of . Future Microbiol. Klebsiella pneumoniae, Bloodstream infection, Epidemiology, Carbapenem resistance, Mortality Go to: Background (KP) is an important pathogen responsible for severe diseases such as septicemia, pneumonia, urinary tract infections, and soft tissue infections, and this pathogen is mainly associated with community- and hospital-acquired infections [ Detection and prevalence of multidrug-resistant Klebsiella pneumoniae strain isolated from poultry farms in Blitar, Indonesia. Permatasari DA, Witaningrum AM, Wibisono FJ, Effendi MH. Methods: We conducted a retrospective, cross-sectional study of K. pneumoniae strains collected in a hospital in Zhejiang Province, China, from Jan 2014 to Dec 2017. They are commonly found in the environment and in the human . E. coli . Awareness of the role of Klebsiella pneumoniae as an important opportunistic pathogen of the urinary tract in compromised individuals and hospitalized patients has increased over the last decades. The prevalence of CRKP in human and the risk factors that predispose occurrence of CRKP infections need to be determined. Klebsiella pneumoniae are bacteria that normally live in your intestines and feces. producing ESBL- and/or carbapenemases (Ec/Kp-ESBL . The appearance of these hazardous isolates and their global. Abstract. We identified bla KPC-3 (n = 36), bla OXA-181 This study was conducted to investigate the molecular epidemiology of drug resistance in clinical isolates of K. pneumoniae in Azerbaijan, Iran. Of the pathogenic Klebsiella species, K. pneumoniae is the most prevalent and clinically important. It has been observed to develop resistance to antimicrobials more easily than most bacteria. Klebsiella pneumoniae ranks among the top ten organisms causing blood stream infection, pneumonia and other invasive infections in hospitalized patients in different countries [2-4]. Multidrug-resistant strains of Klebsiella pneumoniae are a problem in many hospitals. Klebsiella (K.) pneumoniae as a multi-drug resistant (MDR) pathogen is an emerging challenge for clinicians worldwide. In healthcare settings, Klebsiella bacteria can be spread through person-to-person contact (for example, from patient to patient via the contaminated . Biodiversitas 21: 4642-4647. Submit data. Background and aim. 947 High prevalence of Klebsiella pneumoniae carbapenemase-mediated resistance in K. pneumoniae isolates from Egypt L. Metwally,1 N. Gomaa,1 M. Attallah 2 and N. Kamel 3 ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the bla Learn about its symptoms and treatment. However, studies on the surveillance of multidrug-resistant Klebsiella pneumoniae are very . Klebsiella pneumoniae was an urgently defined threat in the rise of multi-drug-resistant hospitals and hyper virulent strains. The most commonly identified bacteria were Streptococcus pneumoniae (9.1%), Haemophilus influenza (6.5%) and Klebsiella pneumoniae (2.6%). Piazza A, Comandatore F, Romeri F, Brilli M, Dichirico B, Ridolfo A, et al. Identication of VIM-1 bla gene in ST307 and ST661 Klebsiella pneumoniae clones in Italy: old acquaintances for new combinations. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global concern, leading to healthcare-associated infections worldwide. Methods: Minimum inhibitory concentrations (MICs) were evaluated by Etest, colistin MICs were also evaluated by broth microdilution SensiTest (now known . Klebsiella Infections* / epidemiology Klebsiella Infections* / genetics . Materials and Methods. The appearance of these hazardous isolates and their global distribution has left very few . The Pathogenesis and Epidemiology of Klebsiella pneumoniae - Volume 6 Issue 2. The carrier prevalence of K. pneumoniae is substantially higher in hospitalized patients than in the population (Hasan et al . Incidence of ESBL-producing . bkitchel@cdc.gov Search articles by 'Brandon Kitchel' Kitchel B1, A multicentre nationwide surveillance study was conducted in Greek hospitals to evaluate epidemiology of carbapenemase-producing Klebsiella pneumoniae clinical isolates, and their susceptibilities to last-line antibiotics. They also have a high tendency to. Epidemiology Molecular Epidemiology of Klebsiella pneumoniae Strains Causing Bloodstream Infections in Adults Meritxell Cubero , Imma Grau , Fe Tubau , Romn Pallars , M. ngeles Domnguez , Josefina Liares , and Carmen Ardanuy Meritxell Cubero Genomic evolution and local epidemiology of Klebsiella pneumoniae from a major hospital in Beijing, China, over a 15 year period: dissemination of known and novel high-risk clones Mattia Palmieri, Kelly L. Wyres, Caroline Mirande, Zhao Qiang, Ye Liyan, Chen Gang, Herman Goossens, Alex van Belkum, Luo Yan Ping Infectious Diseases Epidemiology of carbapenem resistant Klebsiella pneumoniae colonization in an intensive care unit B. D. Debby, O. Ganor, M. Yasmin, L. David, K. Nathan, T. Ilana, S. Dalit, G. Smollan & R. Galia European Journal of Clinical Microbiology & Infectious Diseases 31 , 1811-1817 ( 2012) Cite this article 1564 Accesses 50 Citations 6 Altmetric Metrics K. pneumoniae . How Klebsiella bacteria are spread. Doctors typically use antibiotics to treat it. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Clinical epidemiology of Klebsiella pneumoniae carbapenemases The Review by Silvia Munoz-Price and colleagues emphasises the importance of Klebsiella pneumoniae strains that produce K pneumoniae carbapenemases (KPC-KP) that have taught the medical community to fear rapid in-hospital transmission and excess mortality caused by carbapenem resistance. Klebsiella pneumoniae is one of the top three bacteria of international concern in the 2014 WHO report on the global status of antibacterial resistance ( WHO, 2014 ). To determine whether the etiological agent for CAP varied with age, we compared the prevalence of respiratory pathogens in different age groups. Klebsiella pneumoniae ( K. pneumoniae) has emerged as a major pathogen of international concern due to the increasing incidences of hypervirulent and carbapenem-resistant strains. Klebsiella pneumoniae can normally colonize the oropharynx and the gastrointestinal tract. We identified 217 unique patient BSIs, including 92 (42%) KPC-positive, 49 (23%) ESBL-positive, and 1 (0.5%) metallo-beta-lactamase-positive isolates. Mechanisms of antimicrobial resistance are inactivation of compounds via enzymes, change of membrane permeability, and alteration of the target site of . Background Extended-spectrum beta-lactamase (ESBL) producing bacteria present an ever-growing burden in the hospital and community settings. Klebsiella pneumoniae causes serious epidemic and endemic nosocomial infections. Lancet Infect Dis 2009; 9: 228-36. The therapeutic options for infections caused by multidrug-resistant (MDR) K. pneumoniae are often limited. At Kilifi County Hospital (KCH), K. pneumoniae caused 20% of total nosocomial bacteraemia episodes between 2002 and 2009 ( Aiken et al., 2011 ).